The Biosimulation Market has experienced notable growth over the past few years, thanks primarily to a shifting disease landscape and significant developments in digital health tools.
• The market size witnessed a rise from $4.47 billion in 2024 to $5.02 billion in 2025, at a strong compound annual growth rate (CAGR) of 12.2%
Key growth drivers in the historic period include the escalating complexity of diseases, a surge in in silico trials, and a drive to reduce drug development costs amidst an increasing prevalence of chronic diseases.
The biosimulation market is anticipated to witness remarkable momentum in its growth over the coming years.
• By 2029, the market size is projected to reach $9.65 billion, growing at a CAGR of 17.8%.
The forecast period's growth can be attributed to factors such as advancing biosimulation in rare disease research, a focus on pharmacodynamics modeling, patient stratification in clinical trials, continuous advancements in computational biology, and a growing demand for safer, more efficacious drugs.
The rise in global healthcare expenditure is expected to propel the biosimulation market over the forecast period. Heightened healthcare spending is likely to ensure increased funds for drug development, which in turn will drive the revenues generated from biosimulation solutions. Case in point, according to the American Medical Association, U.S. health spending grew by 4.1% in 2022, amounting to $4.5 trillion or $13,493 per person. This uptick in healthcare expenditure significantly supports the growth of the biosimulation market.
The biosimulation market is segmented as follows –
1) By Product: Software, Services
2) By Application: Drug Development, Drug Discovery, Other Applications
3) By End User: Pharmaceutical And Biotechnology Companies, Contract Research Organizations (CROs), Regulatory Authorities, Academic Research Institutions, Other End Users
Product innovation is emerging as a significant trend in the biosimulation market. Many companies in the biosimulation sphere are focusing on developing cutting-edge solutions for biosimulation. For example, in June 2023, Certara, Inc., a Pennsylvania-based firm accelerating drug discovery with proprietary biosimulation software and services, launched the new Phoenix™ Biosimulation Software. Phoenix software enables advanced pharmacokinetic (PK) and pharmacodynamic (PD) modeling, leading to improved drug development efficiency and cost reduction.
Major players operating in the biosimulation market include:
• Certara Inc.
• Dassault Systèmes SE
• Schrödinger Inc.
• Simulations Plus Inc.
• Rhenovia Pharma SAS
• Insilico Biotechnology AG
• Genedata AG
• Entelos Inc.
• Physiomics plc
• Rosa & Co. LLC. and many more
North America was the largest region in the biosimulation market in 2024. Meanwhile, Asia-Pacific is anticipated to be the fastest-growing region in the biosimulation market during the forecast period.