How Has the Progressive Multifocal Leukoencephalopathy Treatment Market Size Evolved in Recent Years?
The progressive multifocal leukoencephalopathy treatment market has seen considerable growth due to a variety of factors.
• The market for progressive multifocal leukoencephalopathy treatment has seen swift expansion in the recent past. The market size is expected to increase from $1.46 billion in 2024 to $1.61 billion in 2025, experiencing a compound annual growth rate (CAGR) of 10.6%.
The historic period's growth was driven by factors such as the increased prevalence of related conditions, a surge in immunosuppressed patients, heightened advocacy and awareness for patients, and the rising HIV/aids prevalence.
What are the Market Size and Expected Growth Rates for the Progressive Multifocal Leukoencephalopathy Treatment Market?
The progressive multifocal leukoencephalopathy treatment market is expected to maintain its strong growth trajectory in upcoming years.
• Anticipated to experience substantial expansion in the years to come, the progressive multifocal leukoencephalopathy treatment market is predicted to increase to a valuation of $2.38 billion by 2029, with a compound annual growth rate (CAGR) of 10.2%.
This projected growth within the forecasted timeframe can be credited to the rise of digital health and telemedicine, evolved diagnostic tools, increased adoption of targeted therapy, and the growing consciousness of progressive multifocal leukoencephalopathy (PML). Key trends expected throughout this forecasting period include the evolution of technology in PML treatments, extensive research and clinical trials, advancements in early diagnosis and screening, and the invention of promising new drug therapies.
Which Key Drivers Are Propelling The Progressive Multifocal Leukoencephalopathy Treatment Market's Growth?
The escalating occurrence of human immunodeficiency virus (HIV) infections is projected to boost the expansion of the progressive multifocal leukoencephalopathy market in the future. HIV is a retrovirus that negatively impacts the immune system by specifically attacking CD4 cells, also referred to as T cells, which are imperative in enabling the body to combat infections. A significant proportion of HIV-positive patients develop progressive multifocal leukoencephalopathy due to a weakened immune system, as evidenced by a decrease in CD4 cell count (200/L), the primary cause for most instances of this disease globally. With the advent of a severe HIV-related immune deficit, the dormant JCV archetype strain in the brain may multiply, resulting in white matter lesions in the brain and progressive multifocal leukoencephalopathy. For example, the Switzerland-based joint venture of the United Nations for AIDS, the Joint United Nations Programme on HIV and AIDS (UNAIDS), reported in December 2022 that there were 630,000 (480,000-880,000) AIDS-related deaths and 39.0 million [33.1 million-45.7 million] individuals living with HIV worldwide. In 2022, an additional 1.3 million [1 million-1.7 million] people were diagnosed with HIV for the first time. Consequently, the surging incidence of human immunodeficiency virus (HIV) infections is contributing to the growth of the progressive multifocal leukoencephalopathy market. The upsurge in research and development as part of the progressive multifocal leukoencephalopathy treatment market is anticipated to fuel its growth. The term 'rising research and development (R&D) activities' suggests that there's an increase in initiatives and investments aimed towards scientific exploration, experimentation, and innovation across various sectors. These activities are of paramount importance for the treatment and control of progressive multifocal leukoencephalopathy in order to develop enhanced therapies, facilitate early diagnosis, and improve disease management. As an illustration, Eurostat, a government agency based in Luxembourg, reported in December 2023 that the EU had allocated €352 billion ($380.40 billion) to R&D in 2022, marking an increase of 6.34% from the €331 billion ($357.71 billion) invested in 2021. Therefore, the increasing R&D activities are propelling the growth of the progressive multifocal leukoencephalopathy treatment market.
What Are The Key Segments Within The Global Progressive Multifocal Leukoencephalopathy Treatment Market?
The progressive multifocal leukoencephalopathy treatment market covered in this report is segmented –
1) By Treatment: Anti-retroviral Therapy, Antiviral Or Anti-John Cunningham Virus (JCV), Other Symptomatic
2) By Indication: HIV Or AIDS, Organ Transplantation, Multiple Sclerosis, Hematologic Malignancies
3) By Route of Administration: Oral, Parenteral, Other Routes Of Administration
4) By End-Users: Hospitals, Homecare, Specialty Centers, Other End-Users
Subsegments:
1) By Anti-retroviral Therapy: NRTIs (Nucleoside Reverse Transcriptase Inhibitors), NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitors), PIs (Protease Inhibitors), Integrase Inhibitors
2) By Antiviral Or Anti-John Cunningham Virus (JCV): Natalizumab, Fumaric Acid Esters, Other JCV-targeted Therapies
3) By Other Symptomatic Treatments: Corticosteroids, Immunomodulators, Supportive Care, Symptomatic Relief Medications
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How Are New Trends Impacting The Size Of The Progressive Multifocal Leukoencephalopathy Treatment Market?
Prominent businesses in the advanced multifocal leukoencephalopathy treatment market are intensifying their efforts towards product innovation as a strategy to offer dependable products to their consumer base and fortify their market standing. A demonstration of this is Cellevolve Bio, an American clinical corporation, that was granted clearance for an investigational new drug (IND) application and orphan drug status for CE-VST01-JC by the United States Food and Drug Administration (FDA) in October 2022. This medication is designed to treat progressive multifocal leukoencephalopathy and will undergo testing in an international, multiple-center, randomized, double-blind, placebo-controlled Phase 2 trial known as ASCEND-JC. The intent of the study is to measure CE-VST01-JC against a placebo to evaluate if CE-VST01-JC can impede or preclude neurological advancement in PML patients. CE-VST01-JC is a T-cell treatment that targets the JC virus, which triggers PML. The inception of the most extensive cell treatment study in PML history, ASCEND-JC, marks a pivotal milestone for both the PML community and Cellevolve Bio.
Who Are the Key Players In The Progressive Multifocal Leukoencephalopathy Treatment Market?
Major companies operating in the progressive multifocal leukoencephalopathy treatment market are:
• Pfizer Inc.
• Johnson & Johnson
• Roche Holding AG
• Merck & Co. Inc.
• AbbVie Inc.
• Novartis AG
• Bristol Myers Squibb Company
• Sanofi S.A.
• Takeda Pharmaceutical Company Limited
• Acorda Therapeutics
• Eli Lilly and Company
• Gilead Sciences Inc.
• Amgen Inc.
• Viatris Inc.
• Teva Pharmaceutical Industries Ltd.
• Biogen Inc.
• Eisai Co. Ltd.
• Otsuka Pharmaceutical Co. Ltd.
• Jazz Pharmaceuticals PLC
• Ipsen Pharma
• Apotex Inc.
• Alkermes PLC
• Alnylam Pharmaceuticals Inc.
• Genentech Inc.
• Karyopharm Therapeutics Inc.
• ARIAD Pharmaceuticals Inc.
• Spectrum Pharmaceuticals
• Neurimmune AG
• NeoImmuneTech
• Inhibikase Therapeutics Inc.
What Are The Regional Insights Into The Progressive Multifocal Leukoencephalopathy Treatment Market?
North America was the largest region in the progressive multifocal leukoencephalopathy treatment market in 2024. The regions covered in the progressive multifocal leukoencephalopathy treatment market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.
