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Organ-on-Chip (OOC) Global Market 2010-2020

Organ-on-Chip (OOC) Global Market 2010-2020

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Including: Lung-on-chip, Heart-on-chip, Liver-on-chip,  Intestine-on-chip, Kidney-on-chip and Human-on-chip, Human disease and tissue models, and Microfluidics.

Historic and Forecast 2010 – 2020

Covering: North America, Europe, Rest Of World (ROW)

This report covers OOCs manufactured by university spinoffs and others. It includes both organ models which are designed on typical chip-like structures and organ models which are designed on microfluidic micrometric plates.


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Description

Organ-on-chip or organ-on-a-chip (OOCs) are microfluidic 3D cell culture devices that closely mimic the key physiological functions of body organs. These chips are usually transparent, flexible and about the size of a computer memory stick. An OOC is also referred to as a biomimetic microsystem or 3D microphysiologic platform or human disease and tissue models‎.

OOCs are one of the most exciting multidisciplinary areas of scientific research. They have the distinguishing characteristic of emulating the human micro environment in vitro, which is not possible by any other conventional in-vitro techniques. This unique feature of an OOC is the result of integrating biology with technology.

Scientific advances in cell biology, microfabrication and microfluidics have led to the development of OOCs. They are tiny chip-like structures with specific embedded cells. The combination of chip and cells in the presence of suitable conditions mimic the key functions of an organ in miniature formats outside the body.

Scientific advances in cell biology, microfabrication and microfluidics have led to the development of Organ-on-Chips (OOCs). OOCs are microfluidic 3D cell culture devices that closely mimic the key physiological functions of body organs. Microchips are not designed to biomimic an entire organ, but simulate the physiology of a single functional unit of an organ system.

These microchips are one of the most exciting areas of scientific research as they have the distinguishing characteristic of emulating the human micro environment in vitro. This unique feature of OOCs is made possible by integrating biology with advanced engineering technologies.

OOCs have potential applications in many major industries including pharmaceutical, agriculture, agrochemicals, chemicals, consumer goods, cosmetics, food and beverages and nutraceuticals, as well as for research. Currently the pharmaceutical industry is dominant in leveraging this technology. The immediate need in the pharmaceutical industry for OOCs is in preclinical testing of drugs. The technology also shows significant potential for drug screening and lead optimization and in fact for use in every aspect of drug discovery and development. Other important potential healthcare applications of OOCs include disease modelling, patient stratification, phenotypic screening and personalized health.

OOC technology is still in an initial stage. The players in the market are basically university spinoffs involved in the commercialization of OOC prototypes developed in the universities. They are few in number. The key players include Emulate, CN-Bio, Mimetas, TissUse, Hurel and Nortis. Currently OOCs are marketed primarily through sales agreements with end users that involve collaboration of both parties in tailoring the OOCs to meet the end user’s requirements.

The global market for OOC devices was valued at $XX million in 2015 and is expected to grow at a rapid compound annual growth rate (CAGR) of XX% to 2020. Up to 2018 the OOC market is expected to rise at this high CAGR due to an increase in number of collaborative sales agreements between the pharmaceutical companies and university spin-offs and the entry of new advanced models of OOC devices into the market. The anticipated launch of humans-on-chips in 2018 will further increase the growth rate from 2018.

Further improvements in the design and manufacture of OOCs will probably replace animal models as subjects in preclinical drug evaluations in future. Overall, they have the potential to break an impasse in in-vitro drug discovery and development.

Additional information
MARKETS COVERED

Organ-on-Chip, Lung-on-chip, Heart-on-chip, Liver-on-chip, Intestine-on-chip, Kidney-on-chip and Human-on-chip, Human disease and tissue models, and Microfluidics.

COMPANIES MENTIONED

CN Bio Innovations, Emulate Inc., TissUse GmbH, Mimetas, HµREL Corporation (HµREL), Nortis, InSphero, Tara Biosystems, and AxoSim Techologies LLC

GEOGRAPHIC SCOPE

North America, Europe and Rest Of World(ROW)

TIME SERIES

Historic and Forecast 2010 to 2020

DATA

Market volume in $ Million

SOURCING AND REFERENCING

Data and analysis throughout the report is sourced using end notes.

Table Of Contents
Global Organ-on-Chip Market 2
List of Figures 5
List of Tables 5
Executive Summary 6
Preface 7
Global Organ-on-Chip Market – Introduction 8
Global Organ-on-Chip Market – Product Analysis 9
Technical Description 9
Typical Organ-on-Chip Structure 9
Product Design Materials 10
Product Designing Methodologies 10
Overview Of Organ Specific Models 10
Lung-on-Chip 11
Heart- on-chip 12
Liver-on-chip 12
Intestine-on-chip 12
Kidney-on-chip 13
Human-on-Chip 13
Global Organ-on-Chip Market – Market Characteristics And Trends 15
Organ-on-Chip Characteristics 15
Organ-on-Chip Origin 15
Organ-on-Chip Features 15
Organ-on-Chip Significance 16
Organ-on-Chip Applications 16
Organ-on-Chip Commercialization 16
Organ-on-Chip Market Penetration 17
Five Force Analysis 17
Trends 18
Manufacturers Tie Up With End-users To Design Tailor-made Products 18
Investment In Integration Of Individual Organ-on-Chips Into Human-on-Chip 19
Strong Focus On Development of Custom Organ-on-Chips 19
Manufacturers Work On Disease Models To Expedite Drug Testing 20
Global Organ-on-Chip Market – Market Size Analysis 21
Global Market For Organ-on-Chips 21
Global Market For Organ-on-Chips (Historic 2010-2015) 21
Global Market For Organ-on-Chips (Forecast 2015-2020) 22
Global Organ-on-Chip Market Segmentation By Organ Type 23
Global Organ-on-Chip Market Segmentation By Geography 24
North America 24
Europe 26
Rest of World (ROW) 28
Global Organ-on-Chip Market – Market Drivers And Restraints 32
Drivers 32
Government Funding Drives The Market For Organ-on-Chips 32
Improved Drug Screening With Organ-on-Chips Will Drive Its Demand 32
Decrease In Drug Testing Costs Using Organ-on-Chips Will Drive Its Demand 33
Restraints 35
Complex Manufacturing Techniques Are A Restraint On Organ-on-Chip Market Growth 35
Requirement For Specialized Equipment Will Be A Challenge For The Organ-on-Chip Market 35
Regulatory Hurdles For Drug Approvals 35
Global Organ-on-Chip Market – Funding Landscape 36
Funding Landscape – USA 36
Funding Landscape – Europe 38
Funding Landscape – ROW 38
Global Organ-on-Chip Market – Competitive Landscape 40
Key Competitor Analysis 40
Key Players in The OOC Market 40
CN Bio Innovations 40
Emulate 42
TissUse 43
Mimetas 44
HµREL 45
Nortis 47
Insphero 48
Tara Biosystems 49
AxoSim Techologies LLC 50
Price Information 50
Global Organ-on-Chip Market – Business Model 52
Academic Universities/Institutes 54
Spinoffs 54
Commercial Industries/End Users 54
Global Organ-on-Chip Market – Customer Analysis 55
End-User Analysis 55
Pharmaceuticals 55
Research Organizations 56
Others 56
End-User Perspective 56
Unmet Needs 56
Appendix 58
Research Methodology 58
Interview Summaries 58
Abbreviations 67
Currencies 68
Research Enquiries 68
The Business Research Company 68
References 68

List Of Tables
Table 1: Global Organ-on-Chip Market, Top Pharmaceutical Companies - R&D Expenditures, 2013 and 2014, Value ($ billions) 33
Table 2: Global Organ-on-Chip Market, Grants Under ‘Tissue Chip for Drug Screening’ Initiative, 2012 36
Table 3: Global Organ-on-Chips Market, Grants Under ‘Tissue Chip for Drug Screening’ Initiative, 2014 37
Table 4: Global Organ-on-Chips Market, CN Bio Collaborations With Pharmaceutical Companies 41
Table 5: Global Organ-on-Chips Market, CN Bio Collaborations With Academic Universities/Institutes 41
Table 6: Global Organ-on-Chips Market, Mimetas’ Collaborations With Industries And Universities 45
Table 7: Global Organ-on-Chips Market, HµREL’s Product Details 46
Table 8: Global Organ-on-Chips Market, Insphero’s Product Portfolio 48
Table 9: Global Organ-on-Chips Market, Academic And Industrial Collaboration Partners Of Insphero 48

List Of Figures
Figure 1: Global Organ-on-Chip Market, Typical Structure Of An Organ-On-Chip 9
Figure 2: Global Organ-on-Chip Market, Lung-on-Chip Model 11
Figure 3: Global Organ-on-Chip Market, Design Of Human-On-Chip Prototype 13
Figure 4: Global Organ-on-Chip Market, Five Force Analysis 18
Figure 5: Global Organ-on-Chip Market, 2010-2015, Value ($ millions) 21
Figure 6: Global Organ-on-Chip Market, 2015-2020, Value ($ millions), 22
Figure 7: Global Organ-on-Chip Market, Segmentation By Organ Type, 2015, Value ($ millions) 23
Figure 8: North America Organ-on-Chip Market Size, 2010-2015, Value ($ millions) 25
Figure 9: North America Organ-on-Chip Market Size, 2015-2020, Value ($ millions) 26
Figure 10: Europe Organ-on-Chips Market Size, 2010-2015, Value ($ millions) 27
Figure 11: Europe Organ-on-Chip Market Size, 2015-2020, Value ($ millions) 28
Figure 12: ROW Organ-on-Chip Market Size, 2010-2015, Value ($ millions) 29
Figure 13: ROW Organ-on-Chips Market Size, 2015-2020, Value ($ million) 30
Figure 14: Global Organ-on-Chip Market, Predictability Scale of Techniques Used in Drug Screening and Evaluation 33
Figure 15: Global Organ-on-Chip Market, Number of New Drug Approvals By FDA and EMA, 2010-2015 34
Figure 16: Global Organ-on-Chip Market, Organ-on-Chips Pricing, 2015 51
Figure 17: Global Organ-on-Chip Market, Typical Business Model Of Organ-on-Chip Companies 53
Figure 18: Global Organ-on-Chips Market, Segmentation By End Users, 2015 ($ million) 55
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