Checkpoint Inhibitors Global Market To Reach Value Of About $40 Billion In 2025

8 Dec, 2021

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The checkpoint inhibitors market consists of sales of the immune checkpoint inhibitor drugs and related services by entities (organizations, sole traders and partnerships) that produce checkpoint inhibitors for treating cancer. A checkpoint inhibitor is a drug that blocks proteins that stop the body’s immune system from killing the cancer cells. One type of cell in the immune system that fights the cancer cells are T-cells. T cells have proteins on them that turn on immune response and other proteins that turn it off. These are called checkpoints. Some checkpoints help T-cells to become active while others help T-cells to switch off. When cancer cells produce high levels of proteins, the switch off checkpoints restrict the immune responses from being strong and sometimes even stops the T-cells from killing the cancer cells. When the checkpoints are blocked by the checkpoint inhibitor from binding with its partner proteins, this allows the T-cells to kill the cancer cells.

Global Checkpoint Inhibitors Market Size And Drivers:

The global checkpoint inhibitors market is expected to grow from $15.29 billion in 2020 to $18.04 billion in 2021 at a compound annual growth rate (CAGR) of 18%. The growth is mainly due to the companies resuming their operations and adapting to the new normal while recovering from the COVID-19 impact, which had earlier led to restrictive containment measures involving social distancing, remote working, and the closure of commercial activities that resulted in operational challenges. The checkpoint inhibitors market is expected to reach $39.81 billion in 2025 at a CAGR of 22%. The rise in the number of cancer cases across the globe is likely to contribute to the growth of the checkpoint inhibitors market during the forecast period.

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Trends In The Global Checkpoint Inhibitors Market

Major companies in the checkpoint inhibitor market are forming partnerships or collaborations for the development of advanced technologies such as bifunctional fusion protein or Y-trap. Most of the patients with cancer do not respond to immune checkpoint inhibitors. To make immunotherapies more effective, a group of researchers has developed the bifunctional fusion protein or Y-trap. This drug is created by fusing a receptor for a protein called TGF-beta that targets checkpoint protein such as PD-L1 or CTLA-4. Y- Trap targets both a checkpoint inhibitor and TGF-beta and gives a more effective way to block the immune suppression and destroys the cancer cells. Merck, a prominent science and technology group, and GSK, a research-based global healthcare company, have announced that they have entered into a global strategic partnership to jointly create and market M7824 (bintrafusp alfa). M7824 is an investigational bi-functional fusion protein immunotherapy that is currently in clinical research, including possible registration trials, for various difficult-to-treat cancers. This includes a Phase II study to investigate M7824 compared to pembrolizumab as a first-line treatment in patients with PD-L1 expressing advanced non-small cell lung cancer (NSCLC). In another instance, in June 2020, Targovax, a Norway-based biotechnology company that develops immune activators for targeting solid tumors, entered into a collaboration with Leidos’ Explorations in Global Health (ExGloH) division for evaluating the potential of using ONCOS, a Targovax's clinical program of oncolytic adenoviruses, as a vector to encode Microtide™ checkpoint inhibitor peptides.

Global Checkpoint Inhibitors Market Segments:
The global checkpoint inhibitor market is further segmented –
By Drug: PD-1 Inhibitors, PD-L1 Inhibitors, CTLA-4, Chimeric Antigen Receptor T-cell, Others
By Application: Lung Cancer, Renal Cancer, Blood Cancer, Bladder Cancer, Melanoma, Others
By End-Users: Hospitals Pharmacies, Retail Pharmacies, Online Pharmacies
By Geography: The global checkpoint inhibitors market is segmented into North America, South America, Asia-Pacific, Eastern Europe, Western Europe, Middle East and Africa.

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Checkpoint Inhibitors Global Market Report 2021 is one of a series of new reports from The Business Research Company that provides checkpoint inhibitors market overviews, analyzes and forecasts market size and growth for the global checkpoint inhibitors market, checkpoint inhibitors market share, checkpoint inhibitors market players, checkpoint inhibitors market segments and geographies, checkpoint inhibitors market’s leading competitors’ revenues, profiles and market shares. The checkpoint inhibitors market report identifies top countries and segments for opportunities and strategies based on market trends and leading competitors’ approaches.