What Has Been The Historical And Current Growth Of The Ligases Enzyme Market?
The ligases enzyme market has seen considerable growth due to a variety of factors.
•Recently, the ligases enzyme market has experienced robust growth. With an anticipated increase from $3.23 billion in 2024 to $3.58 billion in 2025, the market's compound annual growth rate (CAGR) stands at 10.8%.
This impressive historical growth rate has been facilitated by factors such as the pioneering discovery and advancement of ligase enzymes, the expansion of the biotechnology sector, improved knowledge of DNA repair methodologies, the broadening scope of genetic engineering applications, and the escalating demand for molecular diagnostics.
What Is The Forecast For The Ligases Enzyme Market By 2029?
The ligases enzyme market is expected to maintain its strong growth trajectory in upcoming years.
• Expectations are that the ligases enzyme market will experience significant expansion in the coming years, with projections indicating a growth to $5.64 billion in 2029 at a compound annual growth rate (CAGR) of 12.0%.
Factors contributing to this growth during the forecast period include the increased use of personalized medicine, a rising interest in synthetic biology, the use of ligase enzymes in drug development, a surge in demand for molecular diagnostics, and the incorporation of ligases in next-generation sequencing. Key trends anticipated during the forecast period involve the creation of engineered ligases for specific purposes, the use of ligase enzymes in CRISPR-based technologies, the adaptation of ligase-based assays for both research and diagnostics, the emergence of ligase-based isothermal amplification methods, and the implementation of ligase chain reaction (LCR) in diagnostic assays.
What Are The Essential Drivers Behind The Growth Of The Ligases Enzyme Market?
The rising incidence of cancer and genetic abnormalities is predicted to boost the expansion of the market for ligase enzymes. Cancer is a collection of diseases marked by the uncontrolled proliferation and dissemination of aberrant cells, while genetic anomalies refer to a comprehensive spectrum of health complications triggered by irregularities or changes in an individual's genetic makeup, specifically in their DNA. The necessity of ligase enzymes in DNA duplication, mending, and recombination is paramount. In the context of cancer, ligases have the ability to mend compromised DNA, resulting in uncontrollable cell propagation. Ligases also have the potential to target and eliminate cells affected by genetic diseases. For example, data from the Australian Institute of Health and Welfare, a government agency in Australia, revealed that the count of cancer diagnoses surged from 160,570 in 2022 to 164,694 in 2023, indicating a significant annual increase. This escalating pattern underscores the intensifying instance of cancer in the country, with 403 new cancer diagnoses and 144 cancer-linked fatalities per 100,000 residents. Furthermore, Gene People UK, a charity in the UK, stated in February 2023 that roughly 1 in 25 children suffer from a genetic ailment in the UK. This results in over 2.4 million children and adults dwelling with a genetic condition in the UK, and 30,000 infants and children newly diagnosed each year. Consequently, the escalating incidence of cancer and genetic abnormalities is facilitating the expansion of the ligase enzyme market.
How Is The Global Ligases Enzyme Market Divided Into Key Segments?
The ligases enzyme market covered in this report is segmented –
1) By Type: E. coli DNA ligase, T4 DNA Ligase, Mammalian Ligases, Thermostable Ligases
2) By Source: Microorganisms, Animal, Plant
3) By Application: Ligase Chain Reaction (LCR), Ligase Detection Reaction (LDR), Next-Generation Sequencing (NGS), Repeat Expansion Detection (RED), Rolling Circle Amplification (RCA), Proximity Ligation Assay (PLA), Molecular Cloning, Ligation Mediated PCR, Mutation Detection
4) By End-User: Research Laboratories And Institutions, Pharmaceutical And Biopharmaceutical Companies, Diagnostic Laboratories
Subsegments:
1) By E. coli DNA Ligase: Ligase I, Ligase II
2) By T4 DNA Ligase: Wild-Type T4 Ligase, Modified T4 Ligase
3) By Mammalian Ligases: Ligase IV, Ligase I
4) By Thermostable Ligases: Taq DNA Ligase, Pyrococcus Furiosus Ligase
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What Trends Are Reshaping The Future Of The Ligases Enzyme Market?
Leading corporations in the ligases enzyme market are leveraging advanced technologies like nanopore technologies to augment the accuracy and efficiency of DNA sequencing and manipulation, thereby enriching applications in genomics, synthetic biology, and personalized medicine. Nanopore technologies encompass the usage of nanopores to identify and examine molecules, for instance, DNA or proteins, by monitoring alterations in ionic current as they traverse through the pore. As an illustration, in February 2023, the biotechnology company based in the US, Eurofins Genomics, introduced the Express Oxford Nanopore Sequencing service. This service employs Oxford Nanopore technology to sequence lengthy DNA fragments, significantly advantageous for applications that necessitate all-inclusive genomic analysis like metagenomics and detecting structural variants.
Who Are the Key Players in the Ligases Enzyme Market?
Major companies operating in the ligases enzyme market include:
• BASF SE
• F. Hoffmann-La Roche AG
• Thermo Fisher Scientific Inc.
• Merck KGaA
• Agilent Technologies Inc.
• Illumina Inc.
• QIAGEN N.V.
• GenScript
• Promega Corporation
• Oxford Nanopore Technologies Limited
• Takara Bio Inc.
• New England Biolabs Inc.
• BioVision Inc.
• Enzo Life Sciences
• Zymo Research
• LGC Biosearch Technologies
• Genetix Biotech Asia Pvt. Ltd.
• BLIRT S.A.
• Jena Bioscience
• Bioline
• Creative Enzymes
• ArcticZymes Technologies ASA
What are the Regional Insights into the Ligases Enzyme Market?
North America was the largest region in the ligases enzyme market in 2024. Asia-Pacific is expected to be the fastest-growing region in the ligases enzyme market report during the forecast period. The regions covered in the ligases enzyme market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
