The tissue engineered skin substitute market has seen considerable growth due to a variety of factors.
• In recent times, the market size for tissue engineered skin substitutes has seen solid growth. It is forecasted to expand from $1.86 billion in 2024 to $2.03 billion in 2025, reflecting a compound annual growth rate (CAGR) of 8.9%.
The significant growth during the historic period can be credited to augmented funding from government bodies, enhanced focus on personalized medicine, and further increase in financial support from government agencies.
The tissue engineered skin substitute market is expected to maintain its strong growth trajectory in upcoming years.
• The market for tissue engineered skin substitutes is forecasted to experience substantial expansion in the forthcoming years. By 2029, this sector is anticipated to reach a value of $2.82 billion, ballooning at a compound annual growth rate (CAGR) of 8.6%.
Various factors underpin this projected growth, such as the broadening application areas, regulatory clearances, emphasis on sustainability, the proliferation of specialized clinics, as well as enhancement of educational and training programs. During the forecast period, several trends are expected to shape the market, notably advances in biomaterials, improved cellular therapies, increased post-market vigilance, progress in personalized medicine, as well as evolution in consumer tastes.
The tissue-engineered skin substitute market is expected to grow due to the rising rate of accidents. Increased traffic, distracted drivers, poor road maintenance, and increased use of mobile devices while driving are contributing to a higher frequency of accidents. Tissue-engineered skin substitutes serve as functional, biocompatible replacements for damaged skin. They aid in quicker healing and minimize risks such as infections and scarring. For instance, data from the Insurance Institute for Highway Safety and Highway Loss Data Institute, a United States based nonprofit organization, revealed that fatalities from motor vehicle crashes among those 70 and older increased from 5,245 in 2021 to 5,626 in 2022. Hence, the escalating accident rates are fueling the growth of the market for tissue-engineered skin substitutes.
The tissue engineered skin substitute market covered in this report is segmented –
1) By Product: Acellular Skin Substitutes, Biologic Skin Substitute, Cellular Skin Substitutes, Synthetic Skin Substitutes
2) By Material: Synthetic, Natural
3) By Technology: Laser Assisted Bio-Printing, 3-Dimensional (3D), Robotic Technology, Other Technologies
4) By Application: Chronic Wounds, Acute Wounds, Other Applications
5) By End User: Hospital, Specialty Clinics, Ambulatory Surgical Centers, Research Laboratory
Subsegments:
1) By Acellular Skin Substitutes: Decellularized Dermis, Collagen-Based Scaffolds, Amniotic Membrane
2) By Biologic Skin Substitutes: Living Cell-Containing Substitutes, Allogeneic Skin Grafts, Xenogeneic Skin Grafts
3) By Cellular Skin Substitutes: Cultured Epithelial Autografts (CEA), Dermal Substitutes with Cells, Stem Cell-Derived Skin Constructs
4) By Synthetic Skin Substitutes: Polymer-Based Scaffolds, Biodegradable Scaffolds, Hydrogel-Based Substitutes
Leading firms in the tissue-engineered skin substitute market are honing in on the development of sophisticated technologies, like bioprinting technology, to increase the accuracy and effectiveness of crafting intricate skin layers, thereby improving the coherence of skin substitutes with natural skin. Tissue-engineered skin substitutes are benefiting from the use of bioprinting technology, as it allows for the exact construction of complex skin structures via layering cells, biomaterials, and growth catalysts, thereby improving tissue restoration and fusion with natural skin. For example, Avay Biosciences Private Limited, a producer of 3D bioprinters for tissues and organs based in India, introduced the homegrown 3D printer Mito Plus in November 2022, which has the ability to print human tissues. The printer uses specialized materials known as bioinks that mimic living tissues. With features including UV curing options, HEPA filters, and exact temperature regulation, this printer is suited for numerous applications, such as pharmaceutical and cosmetology field's drug discovery and testing.
Major companies operating in the tissue engineered skin substitute market are:
• Stryker Corporation
• DePuy Synthes
• Smith & Nephew Plc
• ConvaTec Group PLC
• Mallinckrodt Pharmaceuticals plc
• Integra LifeSciences Holdings Corporation
• Gunze Limited
• Organogenesis Inc.
• LifeNet Health Inc.
• MiMedx Group Inc.
• Vericel Corporation
• AlloSource Inc.
• Sientra Inc.
• PolyNovo Limited
• Avita Medical Limited
• Tissue Regenix Group
• Amarantus Bioscience Holdings Inc.
• PolarityTE
• Promethean LifeSciences Inc.
• Regenicin Inc.
North America was the largest region in the tissue engineered skin substitute market in 2024. The regions covered in the tissue engineered skin substitute market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.