Normothermic Machine Perfusion Market Report 2026

Normothermic Machine Perfusion Market Overview

• Normothermic Machine Perfusion market size has reached to $1.48 billion in 2025 • Expected to grow to $3.12 billion in 2030 at a compound annual growth rate (CAGR) of 16% • Growth Driver: Growing Demand For Organ Transplantation Driving Market Growth Through Advanced Preservation Techniques • Market Trend: Advancing Organ Preservation Through Research And Innovation • North America was the largest region in 2025.

What Is Covered Under Normothermic Machine Perfusion Market?

Normothermic machine perfusion is a preservation technique in which organs are maintained at normal body temperature (around 37°C) and supplied with oxygenated blood or perfusate to simulate physiological conditions. This method helps improve organ viability, assess function, and extend preservation time before transplantation. The main products in normothermic machine perfusion are portable and stationary normothermic machines. Portable normothermic machine perfusion devices are compact and mobile systems designed to maintain donor organs at a normal body temperature of approximately 37°C during transport. These machines operate using a range of advanced technologies, including mechanical circulation, oxygenation technology, and monitoring technology. Key applications include organ preservation, organ transplantation, and research and development, and they are widely used across various settings such as hospitals, ambulatory surgery centers (ASCs), specialty clinics, and others.

What Is The Normothermic Machine Perfusion Market Growth Forecast?

The normothermic machine perfusion market size is expected to see rapid growth in the next few years. It will grow to $3.12 billion in 2030 at a compound annual growth rate (CAGR) of 16.0%. The growth in the forecast period can be attributed to development of portable and battery-operated machines, advancements in mechanical circulation and oxygenation technologies, rising organ transplantation demand globally, integration with smart monitoring systems, expansion of r&d in organ preservation. Major trends in the forecast period include rising adoption of portable normothermic machines, growing focus on organ viability and extended preservation, integration of advanced monitoring and oxygenation technologies, expansion of organ transplantation programs, increasing use in research and development applications.

Global Normothermic Machine Perfusion Market Segmentation

1) By Product Type: Portable Normothermic Machine, Stationary Normothermic Machine 2) By Technology: Mechanical Circulation Technology, Oxygenation Technology, Monitoring Technology 3) By Application: Organ Preservation, Organ Transplantation, Research And Development 4) By End-User: Hospitals And Ambulatory Surgery Centers (ASCs), Specialty Clinics, Other End-Users Subsegments: 1) By Portable Normothermic Machine: Compact Portable, Battery-Operated Portable Machines, Transport-Friendly Portable Units 2) By Stationary Normothermic Machine: In-Hospital Stationary Machines, Modular Stationary Systems, Advanced Fixed-Location Units

What Is The Driver Of The Normothermic Machine Perfusion Market?

The increasing demand for organ transplantation is expected to propel the growth of the normothermic machine perfusion market going forward. Organ transplantation involves replacing a diseased or non-functioning organ with a healthy one from another person. Organ transplantation is rising due to the increasing prevalence of end-stage organ failure driven by chronic diseases and enhanced surgical and immunosuppressive techniques. Normothermic machine perfusion is used in organ transplantation to preserve and revive donor organs by maintaining them at body temperature with oxygenated blood or perfusate until transplantation. For instance, in January 2024, the U.S. Department of Health & Human Services, a US-based government department, reported that in 2023, a total of 46,632 organ transplants were performed from both living and deceased donors, marking an 8.7% increase compared to 2022. Therefore, the increasing demand for organ transplantation is driving the growth of the normothermic machine perfusion industry.

Key Players In The Global Normothermic Machine Perfusion Market

Major companies operating in the normothermic machine perfusion market are TransMedics Inc., OrganOx Limited, XVIVO Perfusion AB, Organ Recovery Systems Inc., Bridge to Life Ltd., Paragonix Technologies Inc., Lifeline Scientific Inc., LifePort Inc., XENIOS AG, Lung Bioengineering Inc., Waters Medical Systems LLC, Organ Assist B.V., Preservation Solutions Inc., Perfusix AB, Fluent Medical Inc., HemoTherapeutics Inc., Revivicor Inc., Transplant Solutions Inc., BioMedica Diagnostics (Organ Perfusion Division), Advanced Perfusion Systems Inc., Organ Preservation Alliance Technologies, NormaTech Medical Systems

Global Normothermic Machine Perfusion Market Trends and Insights

Major companies operating in the normothermic machine perfusion market are focusing on opening advanced research facilities to accelerate innovation, enhance organ preservation technologies, and improve transplant outcomes. Facility expansion in normothermic machine perfusion enhances capacity for organ preservation, research, and clinical application, improving transplant outcomes and availability. For instance, in May 2024, OrganOx Ltd., a UK-based medical equipment manufacturing company, launched a new 18,000 sq. ft. global research and development and production facility in Oxford to expand innovation and partnerships, following the success of its metra device, which has improved liver transplant outcomes worldwide. This facility expresses optimism about advancing scientific and clinical innovation through technology to better treat organ failure.

What Are Latest Mergers And Acquisitions In The Normothermic Machine Perfusion Market?

In March 2025, OrganOx Limited, a UK-based medical equipment manufacturing company, partnered with Procure On Demand Ltd. to enhance donor liver recovery and evaluation for transplantation. By integrating OrganOx’s NMP system with ProCure’s experienced surgical team and nationwide service network, this collaboration offers adaptable, end-to-end solutions tailored to the diverse needs of transplant centers, ultimately improving transplant efficiency and patient outcomes. Procure On Demand Ltd. is a US-based healthcare company that specializes in human organ transplantation.

Regional Outlook

North America was the largest region in the normothermic machine perfusion market in 2025. The regions covered in this market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in this market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain

What Defines the Normothermic Machine Perfusion Market?

The normothermic machine perfusion market includes revenues earned by entities by providing services such as organ viability assessment, logistics and transport solutions, and organ repair and reconditioning. The market value includes the value of related goods sold by the service provider or included within the service offering. The normothermic machine perfusion market also includes sales of perfusion systems, kits, bioreactors, sensors, and monitoring systems. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

How is Market Value Defined and Measured?

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified). The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.