The Difficult-to-Express Proteins Market Overview 2025 report reveals that the market size has grown significantly over the past few years, with projections indicating further expansion.
The market size of the Difficult-to-Express Proteins Global Market Report 2024 has experienced fast-paced growth recently. The industry is projected to expand from $4.65 billion in 2024 to $5.22 billion in 2025, with a compound annual growth rate (CAGR) of 12.1%.
The market size for difficult-to-express proteins is expected to reach $8.05 billion in 2029, expanding at a compound annual growth rate (CAGR) of 11.4%.
Download Your Free Sample of the 2025 Difficult-to-Express Proteins Market Report and Uncover Key Trends Now!The key drivers in the difficult-to-express proteins market are:
• Development of novel expression systems
• Advancements in next-generation gene editing tools
• Improvement in cell-free systems and protein engineering
• Integration of AI and machine learning technology
The difficult-to-express proteins market covered in this report is segmented –
1) By Protein: Proteases, Kinases, Membrane Proteins, Other Proteins
2) By Expression Of Difficult Proteins: Disulfide-bonded Protein Expression, Membrane Protein Expression, Toxic Protein Expression, Target Protein Insolubility
3) By Technology: Cell-free Protein Synthesis, Prokaryotic Expression Systems, Small Ubiquitin-like Modifier (SUMO) Fusion System, Gene Fusion Systems, Other Technologies
4) By Application: Drug Discovery, Protein Purification, Protein Therapeutics, Disease Diagnostics And Monitoring, Other Applications
The key trends in the difficult-to-express proteins market are:
• Development of novel expression systems and advanced gene editing tools are driving trends.
• The integration of AI and machine learning technologies are increasingly influencing the market.
• Innovations in protein folding technologies and synthetic biology applications are emerging trends.
• Advances in biophysical characterization and expansive use of CRISPR/CAS technology are shaping the future of the market.
The major players in the difficult-to-express proteins market are:
• Thermo Fisher Scientific Inc
North America was the largest region in the difficult-to-express proteins market in 2024