The gene switch market has seen considerable growth due to a variety of factors.
• In the past few years, the gene switch market has experienced a swift expansion. The market is projected to grow from $0.82 billion in 2024 to $0.93 billion in 2025, marking a Compound Annual Growth Rate (CAGR) of 14.4%.
The growth witnessed in the historic period can be credited to the surge in gene-based clinical trials, advancements in regenerative medicine, a rise in public cognizance of genetic technologies, expanded research in functional genomics, and an escalated demand for genetic testing services.
The gene switch market is expected to maintain its strong growth trajectory in upcoming years.
• In the forthcoming years, the gene switch market is projected to experience a rapid upsurge. The market is predicted to expand to $1.58 billion by 2029, escalating at a compound annual growth rate (CAGR) of 14.1%.
This anticipated growth over the predicted timeline is owing to factors such as the escalating demand for customised medication, growing instances of genetic disorders, increased need for targeted cancer treatment methods, amplified global health initiatives, and the surge in gene switch adoption. Upcoming trends within this period are expected to include technological enhancements, CRISPR-based gene switches, the integration of artificial intelligence, the utilisation of gene switches for gene silencing, and epigenetic gene switches.
The escalating count of genetic disorders is predicted to spur the expansion of the gene switch market in the future. Such disorders are illnesses that occur due to irregularities in a person's DNA, which could be a result of mutations, genetic changes inherited, or chromosomal anomalies. The growth in the occurrence of genetic disorders is primarily due to heightened awareness and diagnostic skills, enhanced healthcare services, and a rising elderly population. Gene switches offer a crucial benefit in managing and treating genetic disorders by allowing accurate regulation of gene expression, hence propelling the creation of targeted and effective treatments. For example, data from the Cystic Fibrosis Trust, a charity based in the UK, showed that the count of registered cystic fibrosis patients in the UK increased from 10,908 in 2021 to 11,148 in 2022, signifying an addition of 240 patients in September 2023. Consequently, the escalating occurrence of genetic disorders fuels the expansion of the gene switch market.
The gene switchmarket covered in this report is segmented –
1) By Type: CAR T Cell Therapies, Gene Therapies, Other Therapies
2) By Payment Model Employed: Upfront Payments, Milestone Payments
3) By Application Area: Management Of Treatment Related Toxicity, Regulation Of Gene Expression, Other Applications
Subsegments:
1) By CAR T Cell Therapies: CD19-Targeted CAR T Cell Therapies, BCMA-Targeted CAR T Cell Therapies, CD22-Targeted CAR T Cell Therapies, Multi-Antigen CAR T Cell Therapies, Next-Generation CAR T Cell Therapies
2) By Gene Therapies: Adenoviral Vector-Based Gene Therapies, Lentiviral Vector-Based Gene Therapies, AAV (Adeno-Associated Virus) Gene Therapies, CRISPR-Cas9 Gene Editing Therapies, RNA Interference-Based Gene Therapies
3) By Other Therapies: Stem Cell Therapies, RNA Therapy, Protein Replacement Therapy, Gene Editing Technologies, Immunotherapy Approaches
Major companies operating in the gene switch market are:
• Bristol-Myers Squibb Company
• Novartis AG
• Charles River Laboratories International Inc.
• bluebird bio Inc.
• Regenxbio Inc.
• Kite Pharma Inc.
• Genomatica Inc.
• Intellia Therapeutics Inc.
• Voyager Therapeutics Inc.
• Precigen Inc.
• Cellectis SA
• Autolus Therapeutics plc
• aceRNA Technologies
• Cartherics Pty Ltd.
• panCELLa Inc.
• Aptamer Group plc
• Bellicum Pharmaceuticals Inc.
• Genocea Biosciences Inc.
• CRISPR Therapeutics AG
North America was the largest region in the gene switch market in 2024. The regions covered in the gene switch market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.