The messenger ribonucleic acid (mrna) synthesis raw materials market has seen considerable growth due to a variety of factors.
•The market size for raw materials used in the synthesis of messenger ribonucleic acid (mRNA) has shown consistent growth over the past few years. Projections indicate an increase from $2.99 billion in 2024 to $3.06 billion in 2025, indicating a compound annual growth rate (CAGR) of 2.5%.
The historical growth of this market can be tied to the progress made in biomedical research, increased interest in vaccines and therapeutics, rising demand for personalized medicine, preparation and response to outbreaks, and the expansion of the biotech industry.
The messenger ribonucleic acid (mrna) synthesis raw materials market is expected to maintain its strong growth trajectory in upcoming years.
• In the upcoming years, experts anticipate a consistent expansion in the market size of messenger ribonucleic acid (mRNA) synthesis raw materials. The market is projected to reach $3.54 billion in 2029, achieving a compound annual growth rate (CAGR) of 3.7%.
The projected growth within this period is credited to factors such as optimization of supply chains, market expansion and commercialization, significant investments in the biotech and pharma sectors, regulatory support and clearances, as well as therapeutic expansion. The period is also expected to witness new market entries, strides in quality control and standardization, matters regarding intellectual property and licensing, global accessibility and equity, and a shift towards sustainable and scalable manufacturing.
The escalation of cancer and chronic conditions is anticipated to drive the expansion of the mRNA synthesis raw materials industry. Cancer refers to a condition where abnormal cells grow uncontrollably, invade nearby tissues, and possibly spread to other parts of the body through the blood and lymphatic systems. Chronic diseases are broadly identified as conditions that last a year or more, require ongoing medical care, hinder daily tasks, or both. mRNA synthesis raw materials play a significant role in aspects like drug discovery, vaccine development, and fabrication of RNA-based therapeutics that offer better immunogenicity, greater efficiency, and reduced production time. These are key in the treatment of cancer and chronic illnesses. For example, the American Cancer Society Facts and Figures, a professional organizations company based in the US, estimated that in 2022, there were about 1.9 million new cancer diagnoses in the US, with 609,360 deaths. In 2023, predictions indicate a minor rise to more than 1.9 million fresh cases and around 609,820 deaths. As a result, the increasing prevalence of cancer and chronic illnesses propels the mRNA synthesis of raw materials.
The messenger ribonucleic acid (mRNA) synthesis raw materials market covered in this report is segmented –
1) By Type: Capping Agents, Nucleotides, Plasmid DNA, Other Types
2) By Applications: Therapeutics Production, Vaccine Production, Other Applications
3) By End-Users: Biotechnology Companies, Pharmaceutical Companies, Research And Academic Institutions, Other End-Users
Subsegments:
1) By Capping Agents: 7-Methyl Guanylate (M7G) Capping Agents, Other Capping Agents
2) By Nucleotides: Natural Nucleotides, Modified Nucleotides, Triphosphate Nucleotides
3) By Plasmid DNA: Linearized Plasmid DNA, Circular Plasmid DNA, High-Purity Plasmid DNA
4) By Other Types: Buffer Solutions, Enzymes, Other Auxiliary Materials
Product innovations are emerging as a leading trend in the mRNA synthesis raw materials market, with major companies focusing on developing novel products to bolster their market position. For example, Thermo Fisher Scientific, a US-based provider of instrumentation, reagents, consumables, and software services, launched Dynabeads Solutions in September 2022. These beads are to be used for scaling GMP-grade synthesis and purification of mRNA for vaccine production. Dynabeads Streptavidin for In Vitro Transcription are designed for easier solid-phase IVT of cell-free mRNA, allowing the DNA template to be used up to six times. This reduces the workload associated with plasmid formation and improves mRNA yield on scales from grams to grams. It will also help design a more efficient pipeline for mRNA companies to accelerate their progression from development to commercialization.
Major companies operating in the messenger ribonucleic acid (mRNA) synthesis raw materials market include:
• Pfizer Inc.
• F. Hoffmann-La Roche AG
• Thermo Fisher Scientific Inc.
• Moderna Inc.
• Agilent Technologies Inc.
• Lonza Group Ltd.
• Eurofins Scientific
• Bio-Rad Laboratories Inc.
• Qiagen N.V.
• Maravai LifeSciences
• Takara Bio Inc.
• GenScript Biotech Corporation
• Promega Corporation
• Abcam plc
• BioLegend Inc.
• Integrated DNA Technologies Inc.
• Sino Biological Inc.
• CureVac N.V.
• LGC Biosearch Technologies
• Enzo Biochem Inc
• Merck KGaA
• GeneCopoeia Inc.
• Bio-Synthesis Inc.
• BOC Sciences Inc
• Bio Basic Inc.
• OriGene Technologies Inc.
• BioCat GmbH
• Creative Biogene
• Jena Bioscience GmbH
• ATDBio Ltd.
North America was the largest region in the mRNA synthesis raw materials market in 2024. The regions covered in the messenger ribonucleic acid (mRNA) synthesis raw materials market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa