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Global Orthobiologics Insights 2025, Forecast To 2034

25 Mar, 2025

How Has the Orthobiologics Market Size Evolved in Recent Years?

The orthobiologics market has seen considerable growth due to a variety of factors.
• The orthobiologics market has seen strong growth. It is expected to increase from $7.08 billion in 2024 to $7.56 billion in 2025, at a compound annual growth rate (CAGR) of 6.7%.
Growth is due to the rising prevalence of orthopedic diseases, a shift to minimally invasive procedures, a growing number of reconstructive surgeries, and increased healthcare spending.

What Is The Forecast For The Orthobiologics Market Size?

The orthobiologics market is expected to maintain its strong growth trajectory in upcoming years.
• The orthobiologics market is expected to grow to $9.7 billion by 2029, at a CAGR of 6.5%.
Growth factors include an aging population, sedentary lifestyles, advances in product development, favorable reimbursement policies, and expanded indications for existing products. Trends include innovations in regenerative medicine, advanced products, and market expansion strategies.

What Are The Essential Drivers Behind The Growth Of The Orthobiologics Market?

The orthobiologics market is projected to experience significant growth due to a rise in road accidents and sports-related injuries. These incidents, which commonly result in damage to the musculoskeletal system, are triggered by factors such as driver distraction, excessive speed, substandard road conditions, overexertion, inadequate gear, and insufficient sports training. Orthobiologics provide an effective solution by facilitating efficient healing of musculoskeletal tissues, alleviating inflammation, and bolstering the body's natural repair mechanisms via utilization of bone grafts, growth factors, stem cells, and platelet-rich plasma. For instance, Eurostat, the statistical office of the European Union based in Europe, stated that in 2022, road accidents claimed 20,653 lives in Europe, a figure that represents a 3.7% increase from the 19,917 fatalities recorded in 2021. Thus, the upsurge in the occurrence of sports injuries and road accidents is anticipated to fuel the progress of the orthobiologics market.

How Is The Global Orthobiologics Market Divided Into Key Segments?

The orthobiologics market covered in this report is segmented –
1) By Product Type: Viscosupplements, Bone Growth Factors, Demineralized Bone Matrix, Synthetic Bone Substitutes, Cellular Allograft, Other Products
2) By Application: Spinal Fusion, Maxillofacial And Dental, Soft Tissue Repair, Reconstructive And Fracture Surgery, Other Applications
3) By End User: Hospitals, Orthopedic Clinics, Ambulatory Surgery Centers, Other End Users Subsegments:
1) By Viscosupplements: Hyaluronic Acid Injections, Gel-Based Viscosupplements, Cross-linked Hyaluronic Acid, Other Viscosupplement Products
2) By Bone Growth Factors: Bone Morphogenetic Proteins (BMPs), Recombinant Human Bone Morphogenetic Proteins (rhBMPs), Platelet-Rich Plasma (PRP), Osteogenic Protein-1 (OP-
1), Growth Factors For Bone Healing
3) By Demineralized Bone Matrix: DBM Grafts, DBM Putty, DBM Sponges, DBM Paste And Chips
4) By Synthetic Bone Substitutes: Calcium Phosphate-Based Substitutes, Calcium Sulfate-Based Substitutes, Tricalcium Phosphate (TCP), Hydroxyapatite (HA), Bioactive Glasses, Other Synthetic Bone Substitutes
5) By Cellular Allograft: Osteocellular Allografts, Mesenchymal Stem Cells (MSCs) Allografts, Bone Marrow-Derived Cellular Allografts, Adipose Tissue-Derived Cellular Allografts
6) By Other Products: Autografts, Collagen-Based Grafts, Synthetic Bone Graft Substitutes (Non-Bioactive), Amniotic Membrane-Based Grafts, Exosome-Based Products, Other Miscellaneous Orthobiologic Products

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What Emerging Trends Are Influencing The Growth Of The Orthobiologics Market?

Prominent entities in the orthobiologics market are focusing on innovative solutions like dry allograft combinations to improve bone healing and fusion in orthopedic procedures. These combinations bring together strong cortical fibers with mineralized cortical bone, delivering structural support and enhancing osteoinductive features, which are crucial for the formation of new bone. To illustrate, in May 2024, Fibrant Liberty allograft, a dry allograft blend integrating strong cortical fibers with mineralized cortical cancellous chips, was unveiled by Isto Biologics, an American biologics-oriented firm. This graft transforms to be flexible when hydrated, allowing it to be adapted to a variety of surgical applications. The increased length and strength of the fibers boost handling, creating a complex network that inhibits graft migration while preserving structural stability.

Who Are the Key Players In The Orthobiologics Market?

Major companies operating in the orthobiologics market are:
• Johnson & Johnson
• Medtronic plc
• Zimmer Biomet
• Arthrex Inc.
• Integra Lifesciences Corporation
• NuVasive Inc.
• Globus Medical
• Bioventus
• MTF Biologics
• ATEC Spine Inc.
• Exactech Inc.
• SeaSpine
• RTI Surgical
• AlloSource
• XTANT MEDICAL
• Spine Wave Inc.
• Bone Biologics Corp.
• Locate Bio Limited
• Wright Medical Group N.V.
• BoneSupport AB
• Graftys
• Regenexx
• Acumed LLC
• Baxter International Inc.
• LifeNet Health

What Are The Regional Insights Into The Orthobiologics Market?

North America was the largest region in the orthobiologics market in 2023. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the orthobiologics market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.