The serine proteases market has seen considerable growth due to a variety of factors.
• The serine proteases market has grown steadily, from $2.26 billion in 2024 to $2.52 billion in 2025, at a CAGR of 11.4%.
This growth is due to the increasing prevalence of diseases related to enzymes, more funding for protease-related research, regulatory support, advancements in genetic engineering, and rising demand for serine proteases in food.
The serine proteases market is expected to maintain its strong growth trajectory in upcoming years.
• The serine proteases market is expected to grow to $3.83 billion by 2029, at a CAGR of 11.0%.
Growth is linked to the expansion of industrial applications, growing awareness and adoption, rising chronic diseases, demand in biotechnology and pharmaceuticals, and digestive disorders. Trends include technological advancements, disease treatment inhibitors, CRISPR adoption, and omics technologies development.
The growth of the serine proteases market is projected to be driven by the burgeoning food and beverage industry. This industry entails all enterprises that produce, process, package, distribute, and market food and drink products. Amplification of the food and beverage industry stems from the growing global populace, people's migration to cities, and advancements in production, processing, and distribution methods to enhance efficiency. Serine proteases' use improves the food and beverage products' quality, taste, and functional properties, aiding industry innovation and efficiency. For instance, the Agriculture and Agri-Food Department of a Canada-based government department reported in October 2023 that processed food and beverage product exports reached an unprecedented peak of $54.3 billion in 2022, a 14.1% increase from the preceding year, and made up 34.7% of the total production value. Hence, the food and beverage industry's expansion is propelling the serine proteases market expansion.
The serine proteases market covered in this report is segmented –
1) By Type: C1R, C1S, C3A, C3B
2) By Application: Digestive System, Blood Coagulation System, Complement System, Other Applications
3) By End-Use: Dietary Supplements, Nutraceuticals, Pharmaceutical, Industrial, Other End-Uses
Subsegments:
1) By C1r: C1r Enzyme Subunit, C1r Inhibitors And Modulators, C1r Activity Assays, Recombinant C1r Proteins
2) By C1s: C1s Enzyme Subunit, C1s Inhibitors And Modulators, C1s Activity Assays, Recombinant C1s Proteins
3) By C3a: C3a Receptor Agonists, C3a Peptides, C3a Receptor Antagonists, C3a Activity Assays
4) By C3b: C3b Fragment (Activated C3), C3b Receptor Interactions, C3b Inhibitors And Modulators, C3b Activity Assays
Leading corporations in the serine protease sector are focusing their efforts on innovating new solutions, like protease enzymes, aimed at improving drug effectiveness, industrial processes, and pioneering advanced personal care formulations. This innovation-driven mindset fuels growth and caters to particular market requirements across diverse business sectors. Protease enzymes are bio-catalysts that aid in the breakdown of proteins into smaller peptides or amino acids through cleavage of peptide chains. An example of this is Biocatalysts Ltd., a biotechnology firm located in the UK, that in May 2024 introduced PromodTM 327L and PromodTM 295L. These are innovative protease enzymes designed to boost the effective hydrolysis of collagen into flavor-neutral, low molecular-weight peptides. They offer advantages like enhanced taste, speedier processing times, and flexibility for use in dietary supplements, cosmetics and biomedical usage.
Major companies operating in the serine proteases market are:
• BASF SE
• Thermo Fisher Scientific Inc.
• Roche Holdings Inc.
• Merck KGaA
• Lonza Group
• Novozymes A/S
• QIAGEN N.V.
• GenScript Biotech Corporation
• Promega Corporation
• BioLegend Inc.
• R&D Systems Inc.
• Sino Biological Inc.
• Codexis Inc.
• New England Biolabs Inc.
• BBI Solutions Ltd.
• BRAIN Biotech AG
• Cayman Chemical Company
• RayBiotech Inc.
• BioCat GmbH
• Enzo Life Sciences Inc.
• ProSpec-Tany TechnoGene Ltd.
Asia-Pacific was the largest region in the serine proteases market in 2023. The regions covered in the serine proteases market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.